منابع مشابه
Cellular functions of the DUBs.
Ubiquitylation is a reversible post-translational modification that has emerged as a key regulator of most complex cellular processes. It may rival phosphorylation in scope and exceed it in complexity. The dynamic nature of ubiquitylation events is important for governing protein stability, maintaining ubiquitin homeostasis and controlling ubiquitin-dependent signalling pathways. The human geno...
متن کاملDUBs at a glance.
Introduction The discovery of protein ubiquitylation three decades ago was the beginning of our understanding of a new mechanism by which proteins are marked for assembly into macromolecular complexes or movement between cellular compartments. The finding that ubiquitylation (the covalent attachment of the small protein ubiquitin to other proteins) targeted proteins for degradation earned Avram...
متن کاملDUBs counteract parkin for efficient mitophagy.
The Parkinson’s disease-associated ubiquitin E3 ligase parkin impacts various cellular processes including the autophagic clearance of defective mitochondria. In this issue of The EMBO Journal, Durcan et al (2014) reveal a novel control mechanism of parkin-mediated mitophagy via the selective removal of atypical K6-linked ubiquitin chains from parkin by the deubiquitinase USP8. Together with re...
متن کاملDUBs, New Members in the Hypoxia Signaling clUb
Cellular protein homeostasis is tightly regulated by ubiquitination. Responsible for target protein ubiquitination is a class of enzymes, the so-called ubiquitin E3 ligases. They are opposed to a second class of enzymes, called deubiquitinating enzymes (DUBs), which can remove polyubiquitin chains from their specific target proteins. The coaction of the two sets of enzymes allows the cell to ad...
متن کاملNovel Diubiquitin Probes Expand the Chemical Toolkit to Study DUBs.
Linkage-specific DUBs employ different mechanisms to recognize and cleave polyubiquitin chains of specific linkage types. In this issue of Cell Chemical Biology, Flierman et al. (2016) develop a new family of novel non-hydrolyzable diubiquitin probes that will be valuable tools to study how DUBs achieve specificity.
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2013
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.2560